TY  - GEN
AU  - Budha,Nageshwar R
AU  - Ji,Tao
AU  - Musib,Luna
AU  - Eppler,Steve
AU  - Dresser,Mark
AU  - Chen,Yuan
AU  - Jin,Jin Y
TI  - Evaluation of Cytochrome P450 3A4-Mediated Drug-Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation
SN  - 1179-1926
PY  - 2017///0911
KW  - Administration, Oral
KW  - Alkynes
KW  - Area Under Curve
KW  - Azetidines
KW  - pharmacokinetics
KW  - Benzoxazines
KW  - pharmacology
KW  - Computer Simulation
KW  - Cyclopropanes
KW  - Cytochrome P-450 CYP3A
KW  - metabolism
KW  - Cytochrome P-450 CYP3A Inducers
KW  - Cytochrome P-450 CYP3A Inhibitors
KW  - Diltiazem
KW  - Drug Interactions
KW  - Erythromycin
KW  - Fluvoxamine
KW  - Humans
KW  - Models, Biological
KW  - Piperidines
KW  - Retrospective Studies
KW  - Rifampin
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1007/s40262-016-0412-5
ER  -