TY - GEN AU - Caetano,Mauricio S AU - Zhang,Huiyuan AU - Cumpian,Amber M AU - Gong,Lei AU - Unver,Nese AU - Ostrin,Edwin J AU - Daliri,Soudabeh AU - Chang,Seon Hee AU - Ochoa,Cesar E AU - Hanash,Samir AU - Behrens,Carmen AU - Wistuba,Ignacio I AU - Sternberg,Cinthya AU - Kadara,Humam AU - Ferreira,Carlos Gil AU - Watowich,Stephanie S AU - Moghaddam,Seyed Javad TI - IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras-Mutant Lung Cancer SN - 1538-7445 PY - 2017///0728 KW - Adenocarcinoma KW - drug therapy KW - Animals KW - Antibodies, Monoclonal KW - pharmacology KW - Apoptosis KW - Blotting, Western KW - Carcinogenesis KW - Carcinoma, Non-Small-Cell Lung KW - Cell Proliferation KW - Disease Models, Animal KW - Disease Progression KW - Humans KW - Immunoenzyme Techniques KW - Interleukin-6 KW - antagonists & inhibitors KW - Lung Neoplasms KW - Mice KW - Mutation KW - genetics KW - NF-kappa B KW - Neoplasm Staging KW - Prognosis KW - Proto-Oncogene Proteins p21(ras) KW - Pulmonary Disease, Chronic Obstructive KW - RNA, Messenger KW - Real-Time Polymerase Chain Reaction KW - Reverse Transcriptase Polymerase Chain Reaction KW - STAT3 Transcription Factor KW - Signal Transduction KW - Survival Rate KW - Tumor Cells, Cultured KW - Tumor Microenvironment KW - drug effects N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1158/0008-5472.CAN-15-2840 ER -