TY  - GEN
AU  - Güler-Gane,Gülin
AU  - Kidd,Sara
AU  - Sridharan,Sudharsan
AU  - Vaughan,Tristan J
AU  - Wilkinson,Trevor C I
AU  - Tigue,Natalie J
TI  - Overcoming the Refractory Expression of Secreted Recombinant Proteins in Mammalian Cells through Modification of the Signal Peptide and Adjacent Amino Acids
SN  - 1932-6203
PY  - 2017///0710
KW  - Alkaline Phosphatase
KW  - metabolism
KW  - Amino Acids
KW  - Biological Transport
KW  - Culture Media, Conditioned
KW  - chemistry
KW  - Genetic Vectors
KW  - HEK293 Cells
KW  - Humans
KW  - Interferon-alpha
KW  - Protein Processing, Post-Translational
KW  - Protein Sorting Signals
KW  - Recombinant Proteins
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1371/journal.pone.0155340
ER  -