TY  - GEN
AU  - Toyn,Jeremy H
AU  - Boy,Kenneth M
AU  - Raybon,Joseph
AU  - Meredith,Jere E
AU  - Robertson,Alan S
AU  - Guss,Valerie
AU  - Hoque,Nina
AU  - Sweeney,Francis
AU  - Zhuo,Xiaoliang
AU  - Clarke,Wendy
AU  - Snow,Kimberly
AU  - Denton,R Rex
AU  - Zuev,Dmitry
AU  - Thompson,Lorin A
AU  - Morrison,John
AU  - Grace,James
AU  - Berisha,Flora
AU  - Furlong,Michael
AU  - Wang,Jun-Sheng
AU  - Lentz,Kimberly A
AU  - Padmanabha,Ramesh
AU  - Cook,Lynda
AU  - Wei,Cong
AU  - Drexler,Dieter M
AU  - Macor,John E
AU  - Albright,Charlie F
AU  - Gasior,Maciej
AU  - Olson,Richard E
AU  - Hong,Quan
AU  - Soares,Holly D
AU  - AbuTarif,Malaz
AU  - Ahlijanian,Michael K
TI  - Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects
SN  - 1521-0103
PY  - 2017///0523
KW  - Amyloid Precursor Protein Secretases
KW  - metabolism
KW  - Amyloid beta-Peptides
KW  - antagonists & inhibitors
KW  - Aniline Compounds
KW  - chemistry
KW  - Animals
KW  - Brain
KW  - drug effects
KW  - Bridged-Ring Compounds
KW  - Cell Line
KW  - Dogs
KW  - Dose-Response Relationship, Drug
KW  - Drug Evaluation, Preclinical
KW  - Female
KW  - Humans
KW  - Macaca fascicularis
KW  - Pyrimidines
KW  - Rats, Sprague-Dawley
KW  - Receptors, Notch
KW  - Species Specificity
KW  - Tissue Distribution
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1124/jpet.116.232249
ER  -