Toyn, Jeremy H <br/><br/>
Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects.  [electronic resource] 

 -  The Journal of pharmacology and experimental therapeutics  07 2016 
 - 125-37 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1521-0103 
<br/><br/><label>Standard No.: </label>10.1124/jpet.116.232249  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Amyloid Precursor Protein Secretases--metabolism<br/>Amyloid beta-Peptides--antagonists & inhibitors<br/>Aniline Compounds--chemistry<br/>Animals<br/>Brain--drug effects<br/>Bridged-Ring Compounds--chemistry<br/>Cell Line<br/>Dogs<br/>Dose-Response Relationship, Drug<br/>Drug Evaluation, Preclinical<br/>Female<br/>Humans<br/>Macaca fascicularis<br/>Pyrimidines--chemistry<br/>Rats, Sprague-Dawley<br/>Receptors, Notch--metabolism<br/>Species Specificity<br/>Tissue Distribution