Wood, Michael R <br/><br/>
Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core.  [electronic resource] 

 -  Bioorganic & medicinal chemistry letters  07 2016 
 - 3029-3033 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural 
<br/><br/><label>ISSN: </label>1464-3405 
<br/><br/><label>Standard No.: </label>10.1016/j.bmcl.2016.05.010  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Allosteric Regulation<br/>Animals<br/>Brain--drug effects<br/>Humans<br/>Microsomes, Liver--metabolism<br/>Piperidines--chemical synthesis<br/>Pyrimidines--chemical synthesis<br/>Quinazolines--chemical synthesis<br/>Rats<br/>Receptor, Muscarinic M4--agonists<br/>Structure-Activity Relationship<br/>Thiophenes--chemical synthesis