TY - GEN AU - Nathwani,Seema-Maria AU - Greene,Lisa M AU - Butini,Stefania AU - Campiani,Giuseppe AU - Williams,D Clive AU - Samali,Afshin AU - Szegezdi,Eva AU - Zisterer,Daniela M TI - The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL‑induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells SN - 1791-2423 PY - 2017///0330 KW - Apoptosis KW - drug effects KW - CASP8 and FADD-Like Apoptosis Regulating Protein KW - biosynthesis KW - Caspase 8 KW - Cell Line, Tumor KW - Drug Resistance, Neoplasm KW - genetics KW - Drug Synergism KW - Gene Expression Regulation, Leukemic KW - Humans KW - Myeloid Cell Leukemia Sequence 1 Protein KW - Oxazepines KW - administration & dosage KW - Phosphatidylinositol 3-Kinases KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma KW - drug therapy KW - Pyrroles KW - Receptors, TNF-Related Apoptosis-Inducing Ligand KW - Signal Transduction KW - TNF-Related Apoptosis-Inducing Ligand N1 - Publication Type: Journal Article UR - https://doi.org/10.3892/ijo.2016.3518 ER -