TY  - GEN
AU  - Panarese,Joseph D
AU  - Cho,Hykeyung P
AU  - Adams,Jeffrey J
AU  - Nance,Kellie D
AU  - Garcia-Barrantes,Pedro M
AU  - Chang,Sichen
AU  - Morrison,Ryan D
AU  - Blobaum,Anna L
AU  - Niswender,Colleen M
AU  - Stauffer,Shaun R
AU  - Conn,P Jeffrey
AU  - Lindsley,Craig W
TI  - Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration
SN  - 1464-3405
PY  - 2017///0620
KW  - Allosteric Regulation
KW  - drug effects
KW  - Animals
KW  - Central Nervous System
KW  - Central Nervous System Agents
KW  - chemical synthesis
KW  - Dose-Response Relationship, Drug
KW  - Drug Discovery
KW  - Heterocyclic Compounds
KW  - Molecular Structure
KW  - Pyridines
KW  - Pyrroles
KW  - Rats
KW  - Receptor, Muscarinic M1
KW  - metabolism
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.bmcl.2016.04.083
ER  -