Panarese, Joseph D <br/><br/>
Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration.  [electronic resource] 

 -  Bioorganic & medicinal chemistry letters  08 2016 
 - 3822-5 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1464-3405 
<br/><br/><label>Standard No.: </label>10.1016/j.bmcl.2016.04.083  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Allosteric Regulation--drug effects<br/>Animals<br/>Central Nervous System--drug effects<br/>Central Nervous System Agents--chemical synthesis<br/>Dose-Response Relationship, Drug<br/>Drug Discovery<br/>Heterocyclic Compounds--chemical synthesis<br/>Molecular Structure<br/>Pyridines--chemical synthesis<br/>Pyrroles--chemical synthesis<br/>Rats<br/>Receptor, Muscarinic M1--metabolism<br/>Structure-Activity Relationship