TY - GEN AU - Li,Shih-Wein AU - Wang,Ching-Ying AU - Jou,Yu-Jen AU - Yang,Tsuey-Ching AU - Huang,Su-Hua AU - Wan,Lei AU - Lin,Ying-Ju AU - Lin,Cheng-Wen TI - SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-β1 via ROS/p38 MAPK/STAT3 pathway SN - 2045-2322 PY - 2018///0326 KW - A549 Cells KW - Animals KW - Disease Models, Animal KW - Early Growth Response Protein 1 KW - metabolism KW - Epithelial Cells KW - Fibrosis KW - Gene Silencing KW - drug effects KW - Glial Fibrillary Acidic Protein KW - Humans KW - Lung KW - cytology KW - Mice, Inbred BALB C KW - Models, Biological KW - NF-kappa B KW - Papain KW - pharmacology KW - Promoter Regions, Genetic KW - genetics KW - RNA, Messenger KW - RNA, Small Interfering KW - Reactive Oxygen Species KW - Severe acute respiratory syndrome-related coronavirus KW - enzymology KW - STAT3 Transcription Factor KW - Signal Transduction KW - Sp1 Transcription Factor KW - Thrombospondin 1 KW - Transforming Growth Factor beta1 KW - biosynthesis KW - Up-Regulation KW - Vimentin KW - p38 Mitogen-Activated Protein Kinases N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/srep25754 ER -