TP53 mutations and protein immunopositivity may predict for poor outcome but also for trastuzumab benefit in patients with early breast cancer treated in the adjuvant setting. [electronic resource]
- Oncotarget May 2016
- 32731-53 p. digital
Publication Type: Journal Article; Multicenter Study
1949-2553
10.18632/oncotarget.9022 doi
Adult Aged Aged, 80 and over Antineoplastic Agents, Immunological--therapeutic use Biomarkers, Tumor--analysis Chemotherapy, Adjuvant Chi-Square Distribution Class I Phosphatidylinositol 3-Kinases--analysis Clinical Trials as Topic DNA Mutational Analysis Disease Progression Disease-Free Survival Female Genetic Predisposition to Disease Greece Humans Immunohistochemistry Kaplan-Meier Estimate Middle Aged Multivariate Analysis Mutation Patient Selection Phenotype Predictive Value of Tests Proportional Hazards Models Prospective Studies Retrospective Studies Risk Factors Time Factors Trastuzumab--therapeutic use Treatment Outcome Triple Negative Breast Neoplasms--chemistry Tumor Suppressor Protein p53--analysis Young Adult