Calcium influx-mediated translocation of m-calpain induces Ku80 cleavage and enhances the Ku80-related DNA repair pathway. [electronic resource]
- Oncotarget May 2016
- 30831-44 p. digital
Publication Type: Journal Article
1949-2553
10.18632/oncotarget.8791 doi
Antineoplastic Agents--pharmacology Calcium--metabolism Calcium Ionophores--pharmacology Calpain--genetics Cell Line Cell-Free System--metabolism DNA Breaks, Double-Stranded DNA End-Joining Repair--physiology Drug Resistance, Neoplasm Epithelial Cells--drug effects Gene Knockdown Techniques Humans Ionomycin--pharmacology Ku Autoantigen--metabolism Molecular Targeted Therapy--methods Neoplasms--drug therapy Protein Binding Protein Domains--physiology Protein Multimerization--physiology Protein Transport--physiology Proteolysis Proteomics RNA Interference RNA, Small Interfering Recombinant Proteins--genetics