TY - GEN AU - Hua,Peiyan AU - Sun,Mei AU - Zhang,Guangxin AU - Zhang,Yifan AU - Song,Ge AU - Liu,Zhenyu AU - Li,Xin AU - Zhang,Xingyi AU - Li,Bingjin TI - Costunolide Induces Apoptosis through Generation of ROS and Activation of P53 in Human Esophageal Cancer Eca-109 Cells SN - 1099-0461 PY - 2017///0203 KW - Acetylcysteine KW - pharmacology KW - Antineoplastic Agents, Phytogenic KW - Apoptosis KW - drug effects KW - Caspase 3 KW - genetics KW - Cell Line, Tumor KW - Cell Proliferation KW - Cell Survival KW - Cyclin-Dependent Kinase Inhibitor p21 KW - agonists KW - Dose-Response Relationship, Drug KW - Epithelial Cells KW - Esophagus KW - Free Radical Scavengers KW - G1 Phase Cell Cycle Checkpoints KW - Gene Expression Regulation KW - Humans KW - Membrane Potential, Mitochondrial KW - Mitochondria KW - Poly(ADP-ribose) Polymerases KW - Proto-Oncogene Proteins c-bcl-2 KW - antagonists & inhibitors KW - Reactive Oxygen Species KW - Sesquiterpenes KW - Signal Transduction KW - Tumor Suppressor Protein p53 KW - bcl-2-Associated X Protein N1 - Publication Type: Journal Article UR - https://doi.org/10.1002/jbt.21810 ER -