TY  - GEN
AU  - Piekielna,Justyna
AU  - De Marco,Rossella
AU  - Gentilucci,Luca
AU  - Cerlesi,Maria Camilla
AU  - Calo',Girolamo
AU  - Tömböly,Csaba
AU  - Artali,Roberto
AU  - Janecka,Anna
TI  - Redoubling the ring size of an endomorphin-2 analog transforms a centrally acting mu-opioid receptor agonist into a pure peripheral analgesic
SN  - 1097-0282
PY  - 2017///0206
KW  - Amino Acid Sequence
KW  - Analgesics
KW  - chemical synthesis
KW  - Analgesics, Opioid
KW  - Animals
KW  - Binding Sites
KW  - Biological Assay
KW  - Blood-Brain Barrier
KW  - drug effects
KW  - Calcium
KW  - metabolism
KW  - Cyclization
KW  - Dimerization
KW  - Humans
KW  - Injections, Intraventricular
KW  - Male
KW  - Mice
KW  - Models, Molecular
KW  - Molecular Docking Simulation
KW  - Oligopeptides
KW  - Pain
KW  - drug therapy
KW  - Peptides, Cyclic
KW  - Protein Binding
KW  - Receptors, Opioid, delta
KW  - chemistry
KW  - Receptors, Opioid, kappa
KW  - Receptors, Opioid, mu
KW  - agonists
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1002/bip.22846
ER  -