Rhapontigenin inhibits TGF-β-mediated epithelial‑mesenchymal transition via the PI3K/AKT/mTOR pathway and is not associated with HIF-1α degradation. [electronic resource]
- Oncology reports May 2016
- 2887-95 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1791-2431
10.3892/or.2016.4664 doi
Antineoplastic Agents--pharmacology Drug Screening Assays, Antitumor Epithelial-Mesenchymal Transition HeLa Cells Humans Hypoxia-Inducible Factor 1, alpha Subunit--metabolism Phosphatidylinositol 3-Kinases--metabolism Proteasome Endopeptidase Complex--metabolism Proteolysis Proto-Oncogene Proteins c-akt--metabolism Signal Transduction Snail Family Transcription Factors--metabolism Stilbenes--pharmacology TOR Serine-Threonine Kinases--metabolism Transforming Growth Factor beta1--physiology Ubiquitination