TY  - GEN
AU  - Chen,Jie-Ru
AU  - Jia,Xiu-Hong
AU  - Wang,Hong
AU  - Yi,Ying-Jie
AU  - Wang,Jian-Yong
AU  - Li,You-Jie
TI  - Timosaponin A-III reverses multi-drug resistance in human chronic myelogenous leukemia K562/ADM cells via downregulation of MDR1 and MRP1 expression by inhibiting PI3K/Akt signaling pathway
SN  - 1791-2423
PY  - 2016///1226
KW  - ATP Binding Cassette Transporter, Subfamily B
KW  - genetics
KW  - Antineoplastic Agents
KW  - pharmacology
KW  - Cell Proliferation
KW  - drug effects
KW  - Cell Survival
KW  - Down-Regulation
KW  - Doxorubicin
KW  - Drug Resistance, Multiple
KW  - Drug Resistance, Neoplasm
KW  - Gene Expression Regulation, Neoplastic
KW  - Humans
KW  - K562 Cells
KW  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive
KW  - drug therapy
KW  - Multidrug Resistance-Associated Proteins
KW  - Phosphatidylinositol 3-Kinases
KW  - Proto-Oncogene Proteins c-akt
KW  - Saponins
KW  - Signal Transduction
KW  - Steroids
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.3892/ijo.2016.3423
ER  -