Chen, Jie-Ru <br/><br/>
Timosaponin A-III reverses multi-drug resistance in human chronic myelogenous leukemia K562/ADM cells via downregulation of MDR1 and MRP1 expression by inhibiting PI3K/Akt signaling pathway.  [electronic resource] 

 -  International journal of oncology  May 2016 
 - 2063-70 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1791-2423 
<br/><br/><label>Standard No.: </label>10.3892/ijo.2016.3423  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>ATP Binding Cassette Transporter, Subfamily B--genetics<br/>Antineoplastic Agents--pharmacology<br/>Cell Proliferation--drug effects<br/>Cell Survival--drug effects<br/>Down-Regulation<br/>Doxorubicin--pharmacology<br/>Drug Resistance, Multiple--drug effects<br/>Drug Resistance, Neoplasm--drug effects<br/>Gene Expression Regulation, Neoplastic--drug effects<br/>Humans<br/>K562 Cells<br/>Leukemia, Myelogenous, Chronic, BCR-ABL Positive--drug therapy<br/>Multidrug Resistance-Associated Proteins--genetics<br/>Phosphatidylinositol 3-Kinases--genetics<br/>Proto-Oncogene Proteins c-akt--genetics<br/>Saponins--pharmacology<br/>Signal Transduction--drug effects<br/>Steroids--pharmacology