Gankyrin activates mTORC1 signaling by accelerating TSC2 degradation in colorectal cancer. [electronic resource]
- Cancer letters 06 2016
- 83-94 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1872-7980
10.1016/j.canlet.2016.03.013 doi
Animals Cell Line, Tumor Cell Proliferation Colorectal Neoplasms--enzymology Enzyme Activation Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Heterografts Humans Kaplan-Meier Estimate Mechanistic Target of Rapamycin Complex 1 Mice, Inbred BALB C Mice, Nude Monomeric GTP-Binding Proteins--metabolism Multiprotein Complexes--metabolism Neoplasm Transplantation Neuropeptides--metabolism Prognosis Proteasome Endopeptidase Complex--genetics Proteolysis Proto-Oncogene Proteins--genetics Ras Homolog Enriched in Brain Protein Signal Transduction TOR Serine-Threonine Kinases--metabolism Time Factors Transfection Tuberous Sclerosis Complex 2 Protein Tumor Burden Tumor Suppressor Proteins--metabolism Up-Regulation