TY - GEN AU - You,Abin AU - Cao,Manqing AU - Guo,Zhigui AU - Zuo,Bingfeng AU - Gao,Junrong AU - Zhou,Hongyuan AU - Li,Huikai AU - Cui,Yunlong AU - Fang,Feng AU - Zhang,Wei AU - Song,Tianqiang AU - Li,Qiang AU - Zhu,Xiaolin AU - Yin,Haifang AU - Sun,Huichuan AU - Zhang,Ti TI - Metformin sensitizes sorafenib to inhibit postoperative recurrence and metastasis of hepatocellular carcinoma in orthotopic mouse models SN - 1756-8722 PY - 2016///1024 KW - Acetyltransferases KW - metabolism KW - Animals KW - Antineoplastic Agents KW - administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols KW - pharmacology KW - Apoptosis KW - drug effects KW - Basic Helix-Loop-Helix Transcription Factors KW - Blotting, Western KW - Carcinoma, Hepatocellular KW - drug therapy KW - Cell Hypoxia KW - Cell Line, Tumor KW - Cell Proliferation KW - Cell Survival KW - Drug Synergism KW - Epithelial-Mesenchymal Transition KW - Humans KW - Hypoglycemic Agents KW - Liver Neoplasms KW - Male KW - Metformin KW - Mice, Inbred BALB C KW - Mice, Nude KW - Neoplasm Metastasis KW - Neoplasm Recurrence, Local KW - Niacinamide KW - Phenylurea Compounds KW - Sorafenib KW - Transcription Factors KW - Xenograft Model Antitumor Assays N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1186/s13045-016-0253-6 ER -