TY  - GEN
AU  - Schwerd,Tobias
AU  - Pandey,Sumeet
AU  - Yang,Huei-Ting
AU  - Bagola,Katrin
AU  - Jameson,Elisabeth
AU  - Jung,Jonathan
AU  - Lachmann,Robin H
AU  - Shah,Neil
AU  - Patel,Smita Y
AU  - Booth,Claire
AU  - Runz,Heiko
AU  - Düker,Gesche
AU  - Bettels,Ruth
AU  - Rohrbach,Marianne
AU  - Kugathasan,Subra
AU  - Chapel,Helen
AU  - Keshav,Satish
AU  - Elkadri,Abdul
AU  - Platt,Nick
AU  - Muise,Alexio M
AU  - Koletzko,Sibylle
AU  - Xavier,Ramnik J
AU  - Marquardt,Thorsten
AU  - Powrie,Fiona
AU  - Wraith,James E
AU  - Gyrd-Hansen,Mads
AU  - Platt,Frances M
AU  - Uhlig,Holm H
TI  - Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease
SN  - 1468-3288
PY  - 2017///0803
KW  - Acetylmuramyl-Alanyl-Isoglutamine
KW  - metabolism
KW  - Adolescent
KW  - Adult
KW  - Anti-Bacterial Agents
KW  - pharmacology
KW  - Autophagy
KW  - drug effects
KW  - Bacteria
KW  - Cells, Cultured
KW  - Child
KW  - Child, Preschool
KW  - Chlorpromazine
KW  - Crohn Disease
KW  - complications
KW  - Dopamine Antagonists
KW  - Female
KW  - Genetic Diseases, X-Linked
KW  - genetics
KW  - Gentamicins
KW  - Granuloma
KW  - Humans
KW  - Imidazoles
KW  - Leukocytes, Mononuclear
KW  - Lysosomes
KW  - Macrophages
KW  - Male
KW  - Mutation
KW  - Niemann-Pick Disease, Type C
KW  - Nod2 Signaling Adaptor Protein
KW  - Protein Kinase Inhibitors
KW  - Pyridazines
KW  - Receptor-Interacting Protein Serine-Threonine Kinase 2
KW  - antagonists & inhibitors
KW  - Tumor Necrosis Factor-alpha
KW  - X-Linked Inhibitor of Apoptosis Protein
KW  - deficiency
KW  - Young Adult
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1136/gutjnl-2015-310382
ER  -