Fairhurst, Robin A <br/><br/>
Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.  [electronic resource] 

 -  Bioorganic & medicinal chemistry letters  Apr 2016 
 - 2057-64 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1464-3405 
<br/><br/><label>Standard No.: </label>10.1016/j.bmcl.2016.02.075  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antineoplastic Agents--chemical synthesis<br/>Cell Proliferation--drug effects<br/>Dose-Response Relationship, Drug<br/>Humans<br/>Imidazoles--chemical synthesis<br/>Mice<br/>Mice, Nude<br/>Molecular Structure<br/>NIH 3T3 Cells<br/>Neoplasms, Experimental--drug therapy<br/>Protein Kinase Inhibitors--chemical synthesis<br/>Pyrazines--chemical synthesis<br/>Pyrimidines--chemical synthesis<br/>Pyrroles--chemical synthesis<br/>Receptor, IGF Type 1--antagonists & inhibitors<br/>Structure-Activity Relationship<br/>Xenograft Model Antitumor Assays