Shukla, Samriddhi
Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis. [electronic resource]
- Scientific reports Feb 2016
- 21860 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
ISSN: 2045-2322
Standard No.: 10.1038/srep21860 doi
Subjects--Topical Terms: A549 Cells Animals Blotting, Western Carcinoma, Non-Small-Cell Lung--chemically induced Cell Line, Tumor Cell Movement--drug effects Cell Proliferation--drug effects Cell Transformation, Neoplastic--drug effects Down-Regulation--drug effects Epithelial-Mesenchymal Transition--drug effects Female Human Umbilical Vein Endothelial Cells Humans Immunoprecipitation Lung Neoplasms--chemically induced Mice Microscopy, Fluorescence Neovascularization, Physiologic--drug effects Nitrosamines--toxicity RNA Interference RNA, Small Interfering--metabolism Transforming Growth Factor beta1--pharmacology Triterpenes--toxicity Wnt Signaling Pathway--drug effects Wnt3 Protein--antagonists & inhibitors Wnt3A Protein--antagonists & inhibitors beta Catenin--metabolism