Integrated genomic approaches identify upregulation of SCRN1 as a novel mechanism associated with acquired resistance to erlotinib in PC9 cells harboring oncogenic EGFR mutation. [electronic resource]
- Oncotarget Mar 2016
- 13797-809 p. digital
Publication Type: Journal Article
1949-2553
10.18632/oncotarget.7318 doi
Animals Apoptosis Biomarkers, Tumor--genetics Carcinogenesis Carcinoma, Non-Small-Cell Lung--drug therapy Cell Proliferation Drug Resistance, Neoplasm--genetics ErbB Receptors--antagonists & inhibitors Erlotinib Hydrochloride--pharmacology Genomics--methods Humans Lung Neoplasms--drug therapy Male Mice Mice, Nude Mutation Nerve Tissue Proteins--genetics Protein Kinase Inhibitors--pharmacology RNA, Small Interfering--genetics Signal Transduction Tumor Cells, Cultured Xenograft Model Antitumor Assays