Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening. [electronic resource]
- Scientific reports Feb 2016
- 19976 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2045-2322
10.1038/srep19976 doi
Bortezomib--pharmacology Cell Membrane--metabolism Drug Discovery Ether-A-Go-Go Potassium Channels--chemistry Gene Expression HEK293 Cells High-Throughput Screening Assays Humans Intracellular Space--metabolism Leupeptins--pharmacology Mutation Proteasome Endopeptidase Complex--metabolism Proteasome Inhibitors--pharmacology Protein Interaction Domains and Motifs Protein Isoforms Protein Transport Schizophrenia--genetics