TY  - GEN
AU  - Li,Hao
AU  - O'Donoghue,Anthony J
AU  - van der Linden,Wouter A
AU  - Xie,Stanley C
AU  - Yoo,Euna
AU  - Foe,Ian T
AU  - Tilley,Leann
AU  - Craik,Charles S
AU  - da Fonseca,Paula C A
AU  - Bogyo,Matthew
TI  - Structure- and function-based design of Plasmodium-selective proteasome inhibitors
SN  - 1476-4687
PY  - 2016///0224
KW  - Animals
KW  - Antimalarials
KW  - adverse effects
KW  - Artemisinins
KW  - pharmacology
KW  - Catalytic Domain
KW  - Cryoelectron Microscopy
KW  - Dose-Response Relationship, Drug
KW  - Drug Design
KW  - Drug Resistance
KW  - Drug Synergism
KW  - Enzyme Activation
KW  - Female
KW  - Humans
KW  - Mice
KW  - Mice, Inbred BALB C
KW  - Models, Molecular
KW  - Plasmodium
KW  - drug effects
KW  - Plasmodium chabaudi
KW  - Plasmodium falciparum
KW  - Proteasome Endopeptidase Complex
KW  - chemistry
KW  - Proteasome Inhibitors
KW  - Protein Subunits
KW  - antagonists & inhibitors
KW  - Species Specificity
KW  - Substrate Specificity
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/nature16936
ER  -