DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors. [electronic resource]
- Journal of medicinal chemistry Mar 2016
- 2163-78 p. digital
Publication Type: Journal Article
1520-4804
10.1021/acs.jmedchem.5b01898 doi
Animals Cell Line, Tumor Crystallography, X-Ray DNA--chemistry Dose-Response Relationship, Drug HT29 Cells Humans Isoxazoles--chemical synthesis Mice Models, Molecular Molecular Structure Oxazepines--chemical synthesis Protein Kinase Inhibitors--chemical synthesis Receptor-Interacting Protein Serine-Threonine Kinases--antagonists & inhibitors Small Molecule Libraries--chemical synthesis Structure-Activity Relationship U937 Cells