Cheng, Hsin-Lin <br/><br/>
Zoledronate blocks geranylgeranylation not farnesylation to suppress human osteosarcoma U2OS cells metastasis by EMT via Rho A activation and FAK-inhibited JNK and p38 pathways.  [electronic resource] 

 -  Oncotarget  Mar 2016 
 - 9742-58 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1949-2553 
<br/><br/><label>Standard No.: </label>10.18632/oncotarget.7138  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Biological Transport--drug effects<br/>Bone Density Conservation Agents--pharmacology<br/>Bone Neoplasms--drug therapy<br/>Cadherins--metabolism<br/>Cell Line, Tumor<br/>Cell Movement--drug effects<br/>Cell Survival--drug effects<br/>Diphosphonates--pharmacology<br/>Diterpenes--pharmacology<br/>Epithelial-Mesenchymal Transition--drug effects<br/>Farnesol--pharmacology<br/>Focal Adhesion Kinase 1--metabolism<br/>Focal Adhesion Protein-Tyrosine Kinases--metabolism<br/>Humans<br/>Imidazoles--pharmacology<br/>JNK Mitogen-Activated Protein Kinases--metabolism<br/>MAP Kinase Signaling System--drug effects<br/>Neoplasm Invasiveness--pathology<br/>Nuclear Proteins--metabolism<br/>Osteoporosis--chemically induced<br/>Osteosarcoma--drug therapy<br/>Phosphorylation--drug effects<br/>Prenylation--drug effects<br/>Proto-Oncogene Proteins pp60(c-src)--metabolism<br/>Snail Family Transcription Factors--metabolism<br/>Twist-Related Protein 1--metabolism<br/>Zoledronic Acid<br/>cdc42 GTP-Binding Protein--metabolism<br/>p38 Mitogen-Activated Protein Kinases--metabolism<br/>rho-Associated Kinases--metabolism