Hata, Aaron N

Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition. [electronic resource] - Nature medicine Mar 2016 - 262-9 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

1546-170X

10.1038/nm.4040 doi


Apoptosis--drug effects
Blotting, Western
Carcinoma, Non-Small-Cell Lung--drug therapy
Cell Cycle--drug effects
Cell Line, Tumor
Cell Survival--drug effects
Drug Resistance, Neoplasm--drug effects
ErbB Receptors--antagonists & inhibitors
Gefitinib
Gene Expression Regulation, Neoplastic--drug effects
Humans
In Vitro Techniques
Lung Neoplasms--drug therapy
Mutation
Protein Kinase Inhibitors--pharmacology
Quinazolines--pharmacology
RNA, Messenger--drug effects
Reverse Transcriptase Polymerase Chain Reaction