TY - GEN AU - Itan,Yuval AU - Shang,Lei AU - Boisson,Bertrand AU - Ciancanelli,Michael J AU - Markle,Janet G AU - Martinez-Barricarte,Ruben AU - Scott,Eric AU - Shah,Ishaan AU - Stenson,Peter D AU - Gleeson,Joseph AU - Cooper,David N AU - Quintana-Murci,Lluis AU - Zhang,Shen-Ying AU - Abel,Laurent AU - Casanova,Jean-Laurent TI - The mutation significance cutoff: gene-level thresholds for variant predictions SN - 1548-7105 PY - 2016///0609 KW - Animals KW - Genetic Predisposition to Disease KW - Genetic Variation KW - Humans KW - Nucleic Acid Amplification Techniques KW - methods N1 - Publication Type: Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/nmeth.3739 ER -