TY  - GEN
AU  - Layton,Mark E
AU  - Reif,Alexander J
AU  - Hartingh,Timothy J
AU  - Rodzinak,Kevin
AU  - Dudkin,Vadim
AU  - Wang,Cheng
AU  - Arrington,Ken
AU  - Kelly,Michael J
AU  - Garbaccio,Robert M
AU  - O'Brien,Julie A
AU  - Magliaro,Brian C
AU  - Uslaner,Jason M
AU  - Huszar,Sarah L
AU  - Fillgrove,Kerry L
AU  - Tang,Cuyue
AU  - Kuo,Yuhsin
AU  - Jacobson,Marlene A
TI  - Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis
SN  - 1464-3405
PY  - 2016///0930
KW  - Allosteric Regulation
KW  - Animals
KW  - Disease Models, Animal
KW  - Drug Evaluation, Preclinical
KW  - Imidazoles
KW  - blood
KW  - Locomotion
KW  - drug effects
KW  - Protein Binding
KW  - Psychotic Disorders
KW  - drug therapy
KW  - Pyridines
KW  - chemistry
KW  - Pyridones
KW  - Rats
KW  - Receptors, Metabotropic Glutamate
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1016/j.bmcl.2016.01.021
ER  -