Discovery of a novel anticancer agent with both anti-topoisomerase I and II activities in hepatocellular carcinoma SK-Hep-1 cells in vitro and in vivo: Cinnamomum verum component 2-methoxycinnamaldehyde. [electronic resource]
- Drug design, development and therapy 2016
- 141-53 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1177-8881
10.2147/DDDT.S93599 doi
Acrolein--analogs & derivatives Animals Antineoplastic Agents, Phytogenic--isolation & purification Apoptosis--drug effects Carcinoma, Hepatocellular--drug therapy Cell Line, Tumor Cell Proliferation--drug effects Cinnamomum zeylanicum--chemistry DNA Topoisomerases, Type I--drug effects DNA Topoisomerases, Type II--drug effects Dose-Response Relationship, Drug Humans Liver Neoplasms--drug therapy Male Membrane Potential, Mitochondrial--drug effects Mice Mice, Inbred BALB C Mice, Nude Xenograft Model Antitumor Assays