Perng, Daw-Shyong

Discovery of a novel anticancer agent with both anti-topoisomerase I and II activities in hepatocellular carcinoma SK-Hep-1 cells in vitro and in vivo: Cinnamomum verum component 2-methoxycinnamaldehyde. [electronic resource] - Drug design, development and therapy 2016 - 141-53 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1177-8881

10.2147/DDDT.S93599 doi


Acrolein--analogs & derivatives
Animals
Antineoplastic Agents, Phytogenic--isolation & purification
Apoptosis--drug effects
Carcinoma, Hepatocellular--drug therapy
Cell Line, Tumor
Cell Proliferation--drug effects
Cinnamomum zeylanicum--chemistry
DNA Topoisomerases, Type I--drug effects
DNA Topoisomerases, Type II--drug effects
Dose-Response Relationship, Drug
Humans
Liver Neoplasms--drug therapy
Male
Membrane Potential, Mitochondrial--drug effects
Mice
Mice, Inbred BALB C
Mice, Nude
Xenograft Model Antitumor Assays