Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation. [electronic resource]
- Molecular psychiatry Mar 2016
- 313-9 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1476-5578
10.1038/mp.2015.211 doi
Animals Antidepressive Agents--pharmacology Cells, Cultured Cerebral Cortex--cytology Cysteine--analogs & derivatives Depression--drug therapy Disease Models, Animal Embryo, Mammalian Exploratory Behavior--drug effects Female Gene Expression Regulation--drug effects HEK293 Cells Humans Ketamine--pharmacology Male Mice, Inbred C57BL Mice, Knockout Monomeric GTP-Binding Proteins--genetics N-Methylaspartate--pharmacology Neurons--drug effects Neuropeptides--genetics Nitric Oxide--genetics Nitric Oxide Synthase Type I--deficiency Nitric Oxide Synthase Type II--deficiency Pregnancy Proteolysis--drug effects Ras Homolog Enriched in Brain Protein S-Nitrosothiols--pharmacology Signal Transduction--drug effects Swimming--psychology TOR Serine-Threonine Kinases--genetics Time Factors