TY - GEN AU - Rodgers,David T AU - Mazagova,Magdalena AU - Hampton,Eric N AU - Cao,Yu AU - Ramadoss,Nitya S AU - Hardy,Ian R AU - Schulman,Andrew AU - Du,Juanjuan AU - Wang,Feng AU - Singer,Oded AU - Ma,Jennifer AU - Nunez,Vanessa AU - Shen,Jiayin AU - Woods,Ashley K AU - Wright,Timothy M AU - Schultz,Peter G AU - Kim,Chan Hyuk AU - Young,Travis S TI - Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies SN - 1091-6490 PY - 2016///0613 KW - Animals KW - Antigens, CD19 KW - immunology KW - Antigens, Neoplasm KW - Azides KW - B-Lymphocytes KW - Basic-Leucine Zipper Transcription Factors KW - Cell Line, Tumor KW - Cytokines KW - metabolism KW - Cytotoxicity, Immunologic KW - Dose-Response Relationship, Immunologic KW - Female KW - Genes, Reporter KW - Genetic Vectors KW - Humans KW - Immunotherapy, Adoptive KW - adverse effects KW - Leukemia, B-Cell KW - therapy KW - Lymphocyte Activation KW - Lymphopenia KW - etiology KW - Mice KW - Mice, Inbred C57BL KW - Mice, Inbred NOD KW - Mice, SCID KW - Phenylalanine KW - analogs & derivatives KW - Protein Engineering KW - methods KW - Receptors, Antigen, T-Cell KW - genetics KW - Recombinant Fusion Proteins KW - Saccharomyces cerevisiae Proteins KW - Sialic Acid Binding Ig-like Lectin 2 KW - Single-Chain Antibodies KW - Structure-Activity Relationship KW - T-Cell Antigen Receptor Specificity KW - T-Lymphocyte Subsets KW - Xenograft Model Antitumor Assays N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural UR - https://doi.org/10.1073/pnas.1524155113 ER -