TY - GEN AU - Mugnaini,Claudia AU - Brizzi,Antonella AU - Ligresti,Alessia AU - AllarĂ ,Marco AU - Lamponi,Stefania AU - Vacondio,Federica AU - Silva,Claudia AU - Mor,Marco AU - Di Marzo,Vincenzo AU - Corelli,Federico TI - Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueous Solubility SN - 1520-4804 PY - 2016///0712 KW - Animals KW - Cell Survival KW - drug effects KW - Cells, Cultured KW - Dose-Response Relationship, Drug KW - Humans KW - Ligands KW - Mice KW - Molecular Structure KW - NIH 3T3 Cells KW - Quinolones KW - chemical synthesis KW - Receptor, Cannabinoid, CB2 KW - antagonists & inhibitors KW - Solubility KW - Structure-Activity Relationship KW - Water KW - chemistry N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1021/acs.jmedchem.5b01559 ER -