HER Specific TKIs Exert Their Antineoplastic Effects on Breast Cancer Cell Lines through the Involvement of STAT5 and JNK. [electronic resource]
- PloS one 2016
- e0146311 p. digital
Publication Type: Journal Article
1932-6203
10.1371/journal.pone.0146311 doi
Afatinib Antineoplastic Agents--pharmacology Apoptosis Breast Neoplasms--drug therapy Cell Line, Tumor Cell Proliferation Drug Resistance, Neoplasm Drug Screening Assays, Antitumor ErbB Receptors--antagonists & inhibitors Female Humans Inhibitory Concentration 50 JNK Mitogen-Activated Protein Kinases--metabolism Lapatinib MAP Kinase Signaling System Morpholines--pharmacology Phosphorylation Protein Kinase Inhibitors--pharmacology Protein Processing, Post-Translational Quinazolines--pharmacology STAT5 Transcription Factor--metabolism