Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120. [electronic resource]
- Cancer discovery Mar 2016
- 300-15 p. digital
Publication Type: Journal Article
2159-8290
10.1158/2159-8290.CD-15-0896 doi
Animals Antineoplastic Agents--chemistry Cell Line, Tumor Cell Transformation, Neoplastic--genetics Disease Models, Animal Drug Resistance, Neoplasm Ectopic Gene Expression Gene Deletion Gene Expression Humans MAP Kinase Signaling System Mice Models, Molecular Phenylurea Compounds--pharmacology Protein Conformation Protein Interaction Domains and Motifs--genetics Protein Kinase Inhibitors--chemistry Protein Multimerization Proto-Oncogene Proteins B-raf--antagonists & inhibitors Pyrimidines--pharmacology Xenograft Model Antitumor Assays