Chen, Shih-Hsun

Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120. [electronic resource] - Cancer discovery Mar 2016 - 300-15 p. digital

Publication Type: Journal Article

2159-8290

10.1158/2159-8290.CD-15-0896 doi


Animals
Antineoplastic Agents--chemistry
Cell Line, Tumor
Cell Transformation, Neoplastic--genetics
Disease Models, Animal
Drug Resistance, Neoplasm
Ectopic Gene Expression
Gene Deletion
Gene Expression
Humans
MAP Kinase Signaling System
Mice
Models, Molecular
Phenylurea Compounds--pharmacology
Protein Conformation
Protein Interaction Domains and Motifs--genetics
Protein Kinase Inhibitors--chemistry
Protein Multimerization
Proto-Oncogene Proteins B-raf--antagonists & inhibitors
Pyrimidines--pharmacology
Xenograft Model Antitumor Assays