TY - GEN AU - Agarwal,Shailesh AU - Loder,Shawn AU - Brownley,Cameron AU - Cholok,David AU - Mangiavini,Laura AU - Li,John AU - Breuler,Christopher AU - Sung,Hsiao H AU - Li,Shuli AU - Ranganathan,Kavitha AU - Peterson,Joshua AU - Tompkins,Ronald AU - Herndon,David AU - Xiao,Wenzhong AU - Jumlongras,Dolrudee AU - Olsen,Bjorn R AU - Davis,Thomas A AU - Mishina,Yuji AU - Schipani,Ernestina AU - Levi,Benjamin TI - Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification SN - 1091-6490 PY - 2016///0613 KW - Activin Receptors, Type I KW - metabolism KW - Adipose Tissue KW - drug effects KW - Animals KW - Burns KW - complications KW - Chondrogenesis KW - Disease Models, Animal KW - Gene Regulatory Networks KW - Humans KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - antagonists & inhibitors KW - Integrases KW - Luminescent Measurements KW - Mesenchymal Stem Cells KW - Mice, Knockout KW - Models, Biological KW - Mustard Compounds KW - pharmacology KW - Ossification, Heterotopic KW - diagnostic imaging KW - Phenylpropionates KW - RNA, Messenger KW - genetics KW - Receptor, Platelet-Derived Growth Factor alpha KW - SOX9 Transcription Factor KW - Signal Transduction KW - Sirolimus KW - Tendons KW - Tenotomy KW - Up-Regulation KW - Wound Healing KW - Wounds and Injuries KW - X-Ray Microtomography N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S UR - https://doi.org/10.1073/pnas.1515397113 ER -