ATP-site binding inhibitor effectively targets mTORC1 and mTORC2 complexes in glioblastoma. [electronic resource]
- International journal of oncology Mar 2016
- 1045-52 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1791-2423
10.3892/ijo.2015.3311 doi
Adenosine Triphosphate--chemistry Binding, Competitive Brain Neoplasms--metabolism Cell Line, Tumor Cell Movement Cell Proliferation Cell Survival Chemotaxis Extracellular Signal-Regulated MAP Kinases--metabolism Glioblastoma--metabolism Humans Indoles--chemistry Insulin--chemistry Mechanistic Target of Rapamycin Complex 1 Mechanistic Target of Rapamycin Complex 2 Multiprotein Complexes--metabolism Phenotype Phosphorylation--drug effects Protein Binding Purines--chemistry S Phase Signal Transduction--drug effects Sirolimus--chemistry TOR Serine-Threonine Kinases--metabolism