TY - GEN AU - Gill,Ronald G AU - Pagni,Philippe P AU - Kupfer,Tinalyn AU - Wasserfall,Clive H AU - Deng,Songyan AU - Posgai,Amanda AU - Manenkova,Yulia AU - Bel Hani,Amira AU - Straub,Laura AU - Bernstein,Philip AU - Atkinson,Mark A AU - Herold,Kevan C AU - von Herrath,Matthias AU - Staeva,Teodora AU - Ehlers,Mario R AU - Nepom,Gerald T TI - A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice SN - 1939-327X PY - 2017///0606 KW - Animals KW - Antibodies, Monoclonal KW - administration & dosage KW - Autoimmune Diseases KW - drug therapy KW - Biomedical Research KW - methods KW - CD3 Complex KW - chemistry KW - Diabetes Mellitus, Type 1 KW - Drug Administration Schedule KW - Drug Therapy, Combination KW - Female KW - Immunoglobulin Fab Fragments KW - Immunotherapy KW - Insulin KW - metabolism KW - Insulin Secretion KW - Insulin-Secreting Cells KW - drug effects KW - Interleukin-1 Receptor Accessory Protein KW - antagonists & inhibitors KW - Interleukin-1beta KW - Mice, Inbred NOD KW - Multicenter Studies as Topic KW - Pilot Projects KW - Receptors, Interleukin-1 Type I KW - Recombinant Fusion Proteins KW - therapeutic use KW - Reproducibility of Results KW - Research Design KW - Specific Pathogen-Free Organisms KW - United States N1 - Publication Type: Comparative Study; Journal Article UR - https://doi.org/10.2337/db15-0492 ER -