Phosphodiesterase 5a Inhibition with Adenoviral Short Hairpin RNA Benefits Infarcted Heart Partially through Activation of Akt Signaling Pathway and Reduction of Inflammatory Cytokines. [electronic resource]
- PloS one 2015
- e0145766 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0145766 doi
Animals Cells, Cultured Cyclic Nucleotide Phosphodiesterases, Type 5--genetics Cytokines--metabolism Disease Models, Animal Heart Failure--metabolism Inflammation Mediators--metabolism Male Mice Mice, Inbred C57BL Myocardial Infarction--metabolism Myocardium--pathology Myofibroblasts--metabolism Phosphodiesterase 5 Inhibitors--pharmacology Proto-Oncogene Proteins c-akt--metabolism RNA, Small Interfering--administration & dosage Signal Transduction