TY  - GEN
AU  - Edmondson,Scott D
AU  - Zhu,Cheng
AU  - Kar,Nam Fung
AU  - Di Salvo,Jerry
AU  - Nagabukuro,Hiroshi
AU  - Sacre-Salem,Beatrice
AU  - Dingley,Karen
AU  - Berger,Richard
AU  - Goble,Stephen D
AU  - Morriello,Gregori
AU  - Harper,Bart
AU  - Moyes,Christopher R
AU  - Shen,Dong-Ming
AU  - Wang,Liping
AU  - Ball,Richard
AU  - Fitzmaurice,Aileen
AU  - Frenkl,Tara
AU  - Gichuru,Loise N
AU  - Ha,Sookhee
AU  - Hurley,Amanda L
AU  - Jochnowitz,Nina
AU  - Levorse,Dorothy
AU  - Mistry,Shruty
AU  - Miller,Randy R
AU  - Ormes,James
AU  - Salituro,Gino M
AU  - Sanfiz,Anthony
AU  - Stevenson,Andra S
AU  - Villa,Katherine
AU  - Zamlynny,Beata
AU  - Green,Stuart
AU  - Struthers,Mary
AU  - Weber,Ann E
TI  - Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder
SN  - 1520-4804
PY  - 2016///0614
KW  - Adrenergic beta-3 Receptor Agonists
KW  - pharmacokinetics
KW  - Animals
KW  - CHO Cells
KW  - Cricetinae
KW  - Cricetulus
KW  - Drug Discovery
KW  - Female
KW  - Humans
KW  - Lipidoses
KW  - chemically induced
KW  - Microsomes, Liver
KW  - drug effects
KW  - Models, Molecular
KW  - Pyrimidinones
KW  - Pyrrolidines
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Receptors, Adrenergic, beta
KW  - Serotonin Plasma Membrane Transport Proteins
KW  - metabolism
KW  - Structure-Activity Relationship
KW  - Urinary Bladder
KW  - Urinary Bladder, Overactive
KW  - drug therapy
KW  - Urination
KW  - X-Ray Diffraction
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/acs.jmedchem.5b01372
ER  -