Edmondson, Scott D <br/><br/>
Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder.  [electronic resource] 

 -  Journal of medicinal chemistry  Jan 2016 
 - 609-23 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/acs.jmedchem.5b01372  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adrenergic beta-3 Receptor Agonists--pharmacokinetics<br/>Animals<br/>CHO Cells<br/>Cricetinae<br/>Cricetulus<br/>Drug Discovery<br/>Female<br/>Humans<br/>Lipidoses--chemically induced<br/>Microsomes, Liver--drug effects<br/>Models, Molecular<br/>Pyrimidinones--pharmacokinetics<br/>Pyrrolidines--pharmacokinetics<br/>Rats<br/>Rats, Sprague-Dawley<br/>Receptors, Adrenergic, beta--drug effects<br/>Serotonin Plasma Membrane Transport Proteins--metabolism<br/>Structure-Activity Relationship<br/>Urinary Bladder--drug effects<br/>Urinary Bladder, Overactive--drug therapy<br/>Urination--drug effects<br/>X-Ray Diffraction