Goyard, David Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition. [electronic resource] - European journal of medicinal chemistry Jan 2016 - 444-454 p. digital Publication Type: Journal Article ISSN: 1768-3254 Standard No.: 10.1016/j.ejmech.2015.12.004 doi Subjects--Topical Terms: AnimalsDiabetes Mellitus, Experimental--drug therapyDiabetes Mellitus, Type 2--drug therapyDisease Models, AnimalDose-Response Relationship, DrugEnzyme Inhibitors--chemical synthesisGlucose--analogs & derivativesGlycogen Phosphorylase--antagonists & inhibitorsHypoglycemic Agents--chemical synthesisIsoxazoles--chemical synthesisMolecular StructureRatsRats, ZuckerSpiro Compounds--chemical synthesisStructure-Activity Relationship