TY  - GEN
AU  - Osorio,Fernando G
AU  - Soria-Valles,Clara
AU  - Santiago-Fernández,Olaya
AU  - Bernal,Teresa
AU  - Mittelbrunn,María
AU  - Colado,Enrique
AU  - Rodríguez,Francisco
AU  - Bonzon-Kulichenko,Elena
AU  - Vázquez,Jesús
AU  - Porta-de-la-Riva,Montserrat
AU  - Cerón,Julián
AU  - Fueyo,Antonio
AU  - Li,Juan
AU  - Green,Anthony R
AU  - Freije,José M P
AU  - López-Otín,Carlos
TI  - Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling
SN  - 1546-170X
PY  - 2016///0524
KW  - Adaptor Proteins, Signal Transducing
KW  - Animals
KW  - Blotting, Western
KW  - CRISPR-Cas Systems
KW  - Caenorhabditis elegans
KW  - Caenorhabditis elegans Proteins
KW  - genetics
KW  - Carrier Proteins
KW  - Flow Cytometry
KW  - Fluorescent Antibody Technique
KW  - Humans
KW  - Immunoprecipitation
KW  - Insulin-Like Growth Factor I
KW  - metabolism
KW  - Mice
KW  - Mice, Knockout
KW  - Microfilament Proteins
KW  - Myeloproliferative Disorders
KW  - Proteasome Endopeptidase Complex
KW  - Proteomics
KW  - Proteostasis Deficiencies
KW  - RNA-Binding Proteins
KW  - Real-Time Polymerase Chain Reaction
KW  - Receptor, IGF Type 1
KW  - Receptor, Insulin
KW  - Signal Transduction
KW  - Ubiquitination
KW  - Zinc Fingers
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/nm.4013
ER  -