TY - GEN AU - Dulmovits,Brian M AU - Appiah-Kubi,Abena O AU - Papoin,Julien AU - Hale,John AU - He,Mingzhu AU - Al-Abed,Yousef AU - Didier,Sebastien AU - Gould,Michael AU - Husain-Krautter,Sehba AU - Singh,Sharon A AU - Chan,Kyle W H AU - Vlachos,Adrianna AU - Allen,Steven L AU - Taylor,Naomi AU - Marambaud,Philippe AU - An,Xiuli AU - Gallagher,Patrick G AU - Mohandas,Narla AU - Lipton,Jeffrey M AU - Liu,Johnson M AU - Blanc,Lionel TI - Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors SN - 1528-0020 PY - 2016///0728 KW - Adult KW - Anemia, Sickle Cell KW - blood KW - Carrier Proteins KW - Erythroid Precursor Cells KW - cytology KW - Erythropoiesis KW - drug effects KW - Fetal Hemoglobin KW - biosynthesis KW - Gene Expression Regulation, Developmental KW - Genetic Vectors KW - genetics KW - Hematopoietic Stem Cells KW - Histone Demethylases KW - Humans KW - Ikaros Transcription Factor KW - Kruppel-Like Transcription Factors KW - Lentivirus KW - Multiple Myeloma KW - Neoplasm Proteins KW - Nuclear Proteins KW - Proteasome Endopeptidase Complex KW - metabolism KW - RNA Interference KW - RNA, Small Interfering KW - Repressor Proteins KW - SOXD Transcription Factors KW - Thalidomide KW - analogs & derivatives KW - Transcription, Genetic KW - beta-Globins KW - gamma-Globins N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1182/blood-2015-09-667923 ER -