Dulmovits, Brian M

Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors. [electronic resource] - Blood Mar 2016 - 1481-92 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1528-0020

10.1182/blood-2015-09-667923 doi


Adult
Anemia, Sickle Cell--blood
Carrier Proteins--blood
Erythroid Precursor Cells--cytology
Erythropoiesis--drug effects
Fetal Hemoglobin--biosynthesis
Gene Expression Regulation, Developmental
Genetic Vectors--genetics
Hematopoietic Stem Cells--drug effects
Histone Demethylases--blood
Humans
Ikaros Transcription Factor--blood
Kruppel-Like Transcription Factors--blood
Lentivirus--genetics
Multiple Myeloma--blood
Neoplasm Proteins--biosynthesis
Nuclear Proteins--blood
Proteasome Endopeptidase Complex--metabolism
RNA Interference
RNA, Small Interfering--genetics
Repressor Proteins
SOXD Transcription Factors--blood
Thalidomide--analogs & derivatives
Transcription, Genetic--drug effects
beta-Globins--biosynthesis
gamma-Globins--biosynthesis