mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy. [electronic resource]
- Proceedings of the National Academy of Sciences of the United States of America Dec 2015
- 15790-7 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1091-6490
10.1073/pnas.1521919112 doi
Animals Autophagy Blotting, Western Cells, Cultured HEK293 Cells Humans Hydroxymethylglutaryl-CoA Synthase--metabolism Immunosuppressive Agents--pharmacology Naphthyridines--pharmacology Proteasome Endopeptidase Complex--metabolism Proteolysis--drug effects Sirolimus--pharmacology TOR Serine-Threonine Kinases--antagonists & inhibitors Time Factors Ubiquitin--metabolism Ubiquitination--drug effects