TY  - GEN
AU  - Chanan-Khan,Asher
AU  - Cramer,Paula
AU  - Demirkan,Fatih
AU  - Fraser,Graeme
AU  - Silva,Rodrigo Santucci
AU  - Grosicki,Sebastian
AU  - Pristupa,Aleksander
AU  - Janssens,Ann
AU  - Mayer,Jiri
AU  - Bartlett,Nancy L
AU  - Dilhuydy,Marie-Sarah
AU  - Pylypenko,Halyna
AU  - Loscertales,Javier
AU  - Avigdor,Abraham
AU  - Rule,Simon
AU  - Villa,Diego
AU  - Samoilova,Olga
AU  - Panagiotidis,Panagiots
AU  - Goy,Andre
AU  - Mato,Anthony
AU  - Pavlovsky,Miguel A
AU  - Karlsson,Claes
AU  - Mahler,Michelle
AU  - Salman,Mariya
AU  - Sun,Steven
AU  - Phelps,Charles
AU  - Balasubramanian,Sriram
AU  - Howes,Angela
AU  - Hallek,Michael
TI  - Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (HELIOS): a randomised, double-blind, phase 3 study
SN  - 1474-5488
PY  - 2016///0628
KW  - Adenine
KW  - analogs & derivatives
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Anemia
KW  - chemically induced
KW  - Antineoplastic Combined Chemotherapy Protocols
KW  - adverse effects
KW  - Atrial Fibrillation
KW  - Bendamustine Hydrochloride
KW  - administration & dosage
KW  - Disease Progression
KW  - Disease-Free Survival
KW  - Double-Blind Method
KW  - Female
KW  - Hemorrhage
KW  - Humans
KW  - Intention to Treat Analysis
KW  - Leukemia, Lymphocytic, Chronic, B-Cell
KW  - drug therapy
KW  - Male
KW  - Middle Aged
KW  - Nausea
KW  - Neutropenia
KW  - Piperidines
KW  - Pyrazoles
KW  - Pyrimidines
KW  - Retreatment
KW  - Rituximab
KW  - Thrombocytopenia
N1  - Publication Type: Clinical Trial, Phase III; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/S1470-2045(15)00465-9
ER  -