TY - GEN AU - Ruscetti,M AU - Dadashian,E L AU - Guo,W AU - Quach,B AU - Mulholland,D J AU - Park,J W AU - Tran,L M AU - Kobayashi,N AU - Bianchi-Frias,D AU - Xing,Y AU - Nelson,P S AU - Wu,H TI - HDAC inhibition impedes epithelial-mesenchymal plasticity and suppresses metastatic, castration-resistant prostate cancer SN - 1476-5594 PY - 2017///0911 KW - Animals KW - Blotting, Western KW - Cell Line, Tumor KW - Disease Models, Animal KW - Epithelial-Mesenchymal Transition KW - drug effects KW - Gene Expression Profiling KW - methods KW - Gene Expression Regulation, Neoplastic KW - Histone Deacetylase Inhibitors KW - pharmacology KW - Humans KW - Hydroxamic Acids KW - Indoles KW - Male KW - Mice, Inbred NOD KW - Mice, Knockout KW - Mice, SCID KW - Mice, Transgenic KW - Mitogen-Activated Protein Kinases KW - metabolism KW - Neoplasm Metastasis KW - PTEN Phosphohydrolase KW - genetics KW - Panobinostat KW - Phosphatidylinositol 3-Kinases KW - Prostatic Neoplasms, Castration-Resistant KW - drug therapy KW - Proto-Oncogene Proteins c-akt KW - Proto-Oncogene Proteins p21(ras) KW - Reverse Transcriptase Polymerase Chain Reaction KW - Signal Transduction N1 - Publication Type: Journal Article UR - https://doi.org/10.1038/onc.2015.444 ER -