TY  - GEN
AU  - Hirata,Yasuko
AU  - Brems,Hilde
AU  - Suzuki,Mayu
AU  - Kanamori,Mitsuhiro
AU  - Okada,Masahiro
AU  - Morita,Rimpei
AU  - Llano-Rivas,Isabel
AU  - Ose,Toyoyuki
AU  - Messiaen,Ludwine
AU  - Legius,Eric
AU  - Yoshimura,Akihiko
TI  - Interaction between a Domain of the Negative Regulator of the Ras-ERK Pathway, SPRED1 Protein, and the GTPase-activating Protein-related Domain of Neurofibromin Is Implicated in Legius Syndrome and Neurofibromatosis Type 1
SN  - 1083-351X
PY  - 2016///0706
KW  - Adaptor Proteins, Signal Transducing
KW  - Amino Acid Transport System A
KW  - Cafe-au-Lait Spots
KW  - genetics
KW  - Epidermal Growth Factor
KW  - metabolism
KW  - Female
KW  - Genes, Reporter
KW  - Genetic Association Studies
KW  - HEK293 Cells
KW  - Humans
KW  - Intracellular Signaling Peptides and Proteins
KW  - chemistry
KW  - Kinetics
KW  - MAP Kinase Signaling System
KW  - Male
KW  - Membrane Proteins
KW  - Models, Molecular
KW  - Mutation, Missense
KW  - Neurofibromatosis 1
KW  - Neurofibromin 1
KW  - Peptide Fragments
KW  - Point Mutation
KW  - Protein Conformation
KW  - Protein Interaction Domains and Motifs
KW  - Proto-Oncogene Proteins p21(ras)
KW  - agonists
KW  - Recombinant Fusion Proteins
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1074/jbc.M115.703710
ER  -